The Role of Inflammation in Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma: Literature Review, Preliminary Data, and Future Experiments
The epithelial-mesenchymal transition (EMT) is a trans-differentiation process of epithelial cells into motile mesenchymal cells. It plays an integral role in embryonic development, wound healing and cancer progression. In this study, we present current knowledge on EMT, including its regulatory genes and their target proteins, and the role of chronic inflammation associated with OSCC in initiating EMT. We will also discuss the preliminary data and suggest potential future experiments.
Author(s): Jisoo Kim, DDS 2023, Rachel Choi, DDS 2023
ADA/Dentsply Student Clinicians of the ADA Award